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br The majority of patients in our study reported engaging
2020-03-24
The majority of patients in our study (61%) reported engaging in SDM with their doctors regarding their decision to have CPM or not. This is a marked increase from the 15% rate of SDM reported by Nekhlyudov et al. of patients who received CPM between 1979 and 1999. As in our study, Nekhlyudov et a
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br In conclusion our gene
2020-03-24
In conclusion, our 8-gene expression classifier has high SN and NPV in a real clinical scenario and this perfor-mance is maintained in non high-risk NMIBC group. If only patients with a positive classifier result would be cystoscopied, 17% of all cystoscopies can be prevented. For a definitive con
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br Platinum Priority Urothelial Cancer br Editorial
2020-03-24
Platinum Priority – Urothelial Cancer Editorial by Rui Henrique, Sandra P. Nunes and Carmen Jeroónimo on pp. 251–252 of this issue A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer Andrew Goodspeed a, Annie Jean a, Ja
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br Consensus score formulation br For the first two comparis
2020-03-17
Consensus score formulation For the first two comparisons (DE analyses), Spectinomycin were ranked by their combined fold-change and significance (FDR-adjusted p value). Fold-changes were ranked directly, with higher ranks assigned to genes with greater positive log2FC (tumor/normal), and vice
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br R Development Core Team R A language
2020-03-17
R Development Core Team (2018). R: A language and environment for statis-tical computing (R Foundation for Statistical Computing). Robinson, M.D., and Oshlack, A. (2010). A scaling normalization method for differential Tirapazamine analysis of RNA-seq data. Genome Biol. 11, R25. Robinson, M
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br Milberg A Wa hlberg R Jakobsson M
2020-03-17
6. Milberg A, Wa˚hlberg R, Jakobsson M, Olsson E, Olsson M, Friedrichsen M. What is a ‘secure base’when death is approaching? A study applying attachment FF-MAS to adult patients' and family members' experiences of palliative home care. Psycho Oncol 2012;21:886e95. 7. Dumont S, Turgeon J, Al
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br Gli luciferase Reporter Assay br NIH T cells
2020-03-17
Gli-luciferase Reporter Assay NIH3T3 Epoprostenol were transfected with 8xGli firefly luciferase reporter plasmid (kindly provided by Aykut Uren at Georgetown University) and were seeded into 96-well plates (20,000 cells/well) and cultured to confluency. The cells were then maintained in DMEM
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SC 236 br Pareja F Geyer F C Marchio
2020-03-17
Pareja, F., Geyer, F.C., Marchio, C., Burke, K.A., Weigelt, B., and Reis-Filho, J.S. (2016). Triple-negative breast cancer: the importance of molecular and histologic subtyping, and recognition of low-grade variants. NPJ Breast Cancer 2, 16036. Penault-Llorca, F., and Viale, G. (2012). Patholog
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ular mechanism difference of PD interaction with PD
2019-11-07
ular mechanism difference of PD-1 interaction with PD-L1 and PD-L2.44 After initiating this trial, the association of MSI-H status with objective response to the antiePD-1 immune checkpoint inhibitors nivolumab and pembrolizumab in CRC was published.15,17 In our study, information on the microsat
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br ALDH activity identifies CSCs in numerous
2019-10-29
ALDH activity identifies CSCs in numerous cancers, including ovarian cancer (Deng et al., 2010; Landen et al., 2010; Silva et al., 2011). Limited numbers of primary human ALDHbright AZD7687 initiate tumors, whereas a 50-fold excess of ALDHdim tumor cells cannot. ALDH used in combination wit
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br As we have seen the presence of NCs
2019-10-22
As we have seen, the presence of NCs limits the ability of gel for-mation below certain gelator concentrations which implies that the amount of NCs can also play an important role in optimal LMWG-NCs composite formulation. Fig. 4 shows that a higher amount of NCs (8 vs 2 and 4%) decreases the elas
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Transmission electron microscopy br Cells
2019-10-21
Transmission electron microscopy Cells were collected and fixed in 2.5% phosphate-buffered glutaraldehyde after cultivated with 50 nM compound 6 for 48 h. All the samples were observed at 80 kV by using a JEM 1410 transmission electron microscope (JEOL, Inc., USA). Confocal microscopy
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br in the vicinity of Trp
2019-10-21
in the vicinity of Trp214 the microenvironment around this residue changes, and this reflects on the emission properties of Trp214. The changes in emission spectra of HSA with the addition of in-creasing amount of 1 are shown in Fig. 14. As the concentration of 1 increases, results may devia