• 2019-10
  • 2019-11
  • 2020-03
  • 2020-07
  • 2020-08
  • 2021-03
  • br Acknowledgments br Authors would like to thank


    Authors would like to thank M.S. M. Diaz-Duarte for the colla-boration in the synthesis of anionic nanogels. This investigation was supported by the National Council of Science and Technology of Mexico (CONACYT) through the following grants: Cátedras CONACYT No707, CB2012-178709, and INFR-2016-269007. We thank S. Pérez-Sicairos and M. Salazar-Gastelum for ICP measurements, and V. Miranda-Soto for NMR measurements. The authors are grateful to three referees for their valuable comments in this Paclitaxel work.
    Appendix A. Supplementary data
    M. Berezovski, A. Kichkailo, Current and prospective protein biomarkers of lung cancer, Cancers 9 (2017) 1–22. [2] World Health Organization, website, visited on: 07-17-2019. [3] National Cancer Institute, website html, visited on: 07-16-2019. [4] American Lung Cancer, website lung-disease-lookup/lung-cancer/resource-library/lung-cancer-fact-sheet.html, vis-ited on: 07-16-2019. [5] American Cancer Society, website, visited on: 07-16-2019. [6] V. Foltinová, L. Svihálková, V. Horváth, P. Sova, J. Hofmanová, R. Janisch,
    M. Yokohira, L.L. Arnold, A.V. Kabanov, S.M. Cohen, T.K. Bronich, Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice, Int. J. Nanomedicine 7 (2012) 2557–2571.
    A. Gonzalez-Urias, et al.
    T. Ito, Intraperitoneal delivery of cisplatin via a hyaluronan-based nanogel / in situ cross-linkable hydrogel hybrid system for peritoneal dissemination of gastric Cancer, Mol. Pharm. 14 (2017) 1305–1313. [26] N.V. Nukolova, H.S. Oberoi, S.M. Cohen, A.V. Kabanov, T.K. Bronich, Folate-de-corated nanogels for targeted therapy of ovarian cancer, Biomaterials 32 (2011) 5417–5426.
    H. Yamaguchi, H. Ishigami, Y. Sakai, J. Kitayama, T. Ito, Production of cisplatin-incorporating hyaluronan nanogels via chelating ligand−metal coordination, Bioconjug. Chem. 27 (2016) 504–508.
    [34] A. Licea-Claveríe, J.A. López-Sánchez, K.F. Arndt, A facile synthesis route for car-boxyaryl-methacrylates: a way to obtain aromatic polyelectrolytes, Des. Monomers Polym. 6 (2003) 67–80.
    [35] M. DíazDuarte-Rodríguez, A. Licea-Claveríe, N.A. Cortez-Lemus, A. Zizumbo-López, Acid core nanogels with poly(ethylene glycol) shell: synthesis, characterization and potential application as controlled drug delivery systems, Memorias del X Simposio Internacional: Investigación Química en la Frontera (2015) 119–120.
    [36] L.A. Manzanares-Guevara, A. Licea-Claverie, F. Paraguay-Delgado, Preparation of stimuli responsive nanogels based on poly(N,N-diethylaminoethyl methacrylate) by a simple “surfactant-free” methodology, Soft Mater. 16 (2018) 37–50.
    [39] P. Quiñonez-Angulo, J. Ruiz-Villegas, A. Licea-Claveríe, A. Ramirez-Jiménez,
    V. Miranda-Soto, I.A. Zapata-González, Kinetic study, thermal analysis and kinetic  Colloids and Surfaces B: Biointerfaces 182 (2019) 110365
    [42] L.A. Manzanares-Guevara, A. Licea-Claverie, I. Oroz-Parra, A. Licea-Navarro, On the cytotoxicity of a cationic tertiary amine PEGylated nanogel as nanocarrier for anticancer therapies, MRS Commun. 8 (2018) 1204–1210.
    affects cellular uptake and intracellular trafficking of chitosan-based Paclitaxel nanoparticles, Biomacromolecules 12 (2011) 2440–2446.
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    Caudatin potentiates the anti-tumor effects of TRAIL against human breast T cancer by upregulating DR5
    Fei Hong-ronga,1, Yuan Chuangb,1, Wang Gui-linga, Zhao Yingb, Li Zhao-juna,b, Du Xinb, Wang Feng-Zeb,
    a School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, PR China
    b School of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, PR China
    Keywords: Background: The ability of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to preferentially
    Caudatin induce apoptosis in transformed cells while sparing most normal cells is well established. However, the intrinsic
    TRAIL and acquired resistance of tumors to TRAIL-induced apoptosis limits its therapeutic applicability.
    DR5 Purpose: We investigated the effect of caudatin, a species of C-21 steroidal glycosides isolated from the roots of
    Cynanchum auriculatum, on TRAIL-induced apoptosis in human breast cancer cells.
    Methods: Cell growth inhibition was evaluated by the CCK-8 assay. The cell cycle distribution was assessed by
    propidium iodide flow cytometry. Apoptosis was determined by TUNEL staining. Protein expression was de-